Genetically Modified Salmonella Destroys Cancer By Provoking An Immune Response, Study Finds

schwit1 quotes a report from San Diego Union-Tribune: A genetically modified bacterium destroys tumors by provoking an immune response, according to a study published Wednesday. Using mice and cultures of human cancer cells, a South Korean-led scientific team demonstrated that Salmonella typhimurium engineered to make a foreign protein caused immune cells called macrophages and neutralizes to mobilize against the cancer. The bacterium came from an attenuated strain that has little infectious potential. Such strains have been tested as vaccines. The protein, called FlaB, is made by a gene in the estuarine bacterium Vibrio vulnificus, a close relative of the cholera bacterium, Vibrio cholerae. Tumors shrank below detectable levels in 11 out of 20 mice injected with the modified Salmonella, said the study, published in Science Translational Medicine. The engineered Salmonella provoke a sustained immune response, in addition to preventing the spread of a human colon cancer implanted in a mouse. The bacterium also were found to be nontoxic, multiplying almost exclusively inside tumors.


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