CRISPR: Chinese Scientists To Pioneer Gene-Editing Trial On Humans

An anonymous reader quotes a report from The Guardian: A team of Chinese scientists will be the first in the world to apply the revolutionary gene-editing technique known as CRISPR on human subjects. Led by Lu You, an oncologist at Sichuan University’s West China hospital in Chengdu, China, the team plan to start testing cells modified with CRISPR on patients with lung cancer in August, according to the journal Nature. CRISPR is a game-changer in bioscience; a groundbreaking technique which can find, cut out and replace specific parts of DNA using a specially programmed enzyme named Cas9. Its ramifications are next to endless, from changing the color of mouse fur to designing malaria-free mosquitoes and pest-resistant crops to correcting a wide swath of genetic diseases like sickle-cell anaemia in humans. The Sichuan University trial, it is important to note, does not edit the germ-line; its effects will not be hereditary. What the researchers plan to do is enroll patients with metastatic non-small cell lung cancer, Nature reported, and for whom other treatment options — including chemotherapy and radiotherapy — have failed. They will then extract immune cells from the patients’ blood and use CRISPR to add a new genetic sequence which will help the patient’s immune system target and destroy the cancer. The cells will then be re-introduced into the patients’ bloodstream. The Guardian does note that CRISPR was approved for human trials in the U.S., but if it begins on schedule in August the Sichuan University study will beat them to the punch of being the first of its kind.


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